We investigated the effectiveness of a sustained and spiraled content literacy intervention that emphasizes building domain and topic knowledge schemas and vocabulary for elementary-grade students. The Model of Reading Engagement (MORE) intervention underscores thematic lessons that provide an intellectual framework for helping students connect new learning to a general schema in Grade 1 (animal survival), Grade 2 (how scientists study past events), and Grade 3 (our human body, a living system that helps us survive). A total of 30 elementary schools (N = 2,870 students) were randomized to a treatment or control condition. In the treatment condition (i.e., full spiral curriculum schools), students participated in content literacy lessons from Grades 1 to 3 during the school year and wide reading of thematically related informational texts in the summer following Grades 1 and 2. In the control condition (i.e., partial spiral curriculum schools), students participated in Grade 3 MORE lessons. Grade 3 lessons for both conditions were implemented online during the COVID-19 pandemic school year. Results reveal that treatment group students outperformed control students on science vocabulary knowledge across all three grades. Furthermore, we found positive transfer effects on Grade 3 science reading (ES = .14), domain-general reading comprehension (ES = .11), and mathematics achievement (ES = .12). Treatment impacts were sustained at 14-month follow-up on Grade 4 reading comprehension (ES = .12) and mathematics achievement (ES = .16). Findings indicate that a content literacy intervention that spirals topics and vocabulary across grades can improve students’ long-term academic achievement outcomes.