The opioid crisis is widely recognized as one of the most important public health emergencies of our time, and an issue that is particularly acute for rural communities. We propose a simple model of how opioids in a community can impact the education outcomes of children based on both the extent of exposure to opioids in the community and the child’s vulnerability to any given level of exposure. Next, we document the spatial dimensions of the intersection of the opioid crisis and standardized test scores using national data, with a focus on rural communities. Finally, we estimate the extent to which variation in one measure of the opioid crisis, drug-related mortality, is related to variation in test scores. We find strong relationships between the two, as well as evidence that the relationship is particularly salient for 3rd grade students in rural communities.